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Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain

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Mossel, E.C., Wang, J., Jeffers, S., Edeen, K.E., Wang, S., Cosgrove, G.P., Funk, C.J., Manzer, R., Miura, T.A., Pearson, L.D., Holmes, K.V